It is a case of familiar territory for Barcelona on Wednesday night as they continue their pursuit of Copa del Rey glory.
On 26 occasions they have lifted the famous trophy, including last season's 3-0 triumph over Athletic Bilbao, which also happened to be Pep Guardiola's final game in charge of the club.
The 2-1 victory over Betis on Sunday maintained the Catalans' unbeaten start to their La Liga season, while also playing host to a moment of footballing history, as Lionel Messi struck his 85th and 86th goals of 2012 to break Gerd Muller's long-standing haul of strikes in a calendar year.
But an injury to Cesc Fabregas means the midfielder will be absent on Tuesday and for up to four weeks with a thigh strain, while a host of changes are to be expected given the close proximity between the two games.
